Identification of new genetic susceptibility loci for breast cancer through consideration of gene-environment interactions

A Schoeps; A Rudolph; P Seibold; AM Dunning; RL Milne; SE Bojesen; A Swerdlow; I Andrulis; H Brenner; S Behrens; N Orr; M Jones; A Ashworth; J Li; H Cramp; D Connley; K Czene; H Darabi; SJ Chanock; J Lissowska; JD Figueroa; J Knight; G Glendon; AM Mulligan; M Dumont; G Severi; L Baglietto; J Olson; C Vachon; K Purrington; M Moisse; P Neven; H Wildiers; A Spurdle; VM Kosma; V Kataja; JM Hartikainen; U Hamann; YD Ko; AK Dieffenbach; V Arndt; C Stegmaier; N Malats; JI Arias Perez; J Benítez; H Flyger; BG Nordestgaard; T Truong; E Cordina-Duverger; F Menegaux; I dos Santos Silva; O Fletcher; N Johnson; L Häberle; MW Beckmann; AB Ekici; L Braaf; F Atsma; AJ van den Broek; E Makalic; DF Schmidt; MC Southey; A Cox; J Simard; GG Giles; D Lambrechts; A Mannermaa; H Brauch; P Guénel; J Peto; PA Fasching; J Hopper; D Flesch-Janys; F Couch; G Chenevix-Trench; PDP Pharoah; M Garcia-Closas; MK Schmidt; P Hall; DF Easton; J Chang-Claude

Journal article

Identification of new genetic susceptibility loci for breast cancer through consideration of gene-environment interactions

A Schoeps, A Rudolph, P Seibold, AM Dunning, RL Milne, SE Bojesen, A Swerdlow, I Andrulis, H Brenner, S Behrens, N Orr, M Jones, A Ashworth, J Li, H Cramp, D Connley, K Czene, H Darabi, SJ Chanock, J Lissowska Show all

Genetic Epidemiology | WILEY | Published : 2014

DOI: 10.1002/gepi.21771

Abstract

Genes that alter disease risk only in combination with certain environmental exposures may not be detected in genetic association analysis. By using methods accounting for gene-environment (G × E) interaction, we aimed to identify novel genetic loci associated with breast cancer risk. Up to 34,475 cases and 34,786 controls of European ancestry from up to 23 studies in the Breast Cancer Association Consortium were included. Overall, 71,527 single nucleotide polymorphisms (SNPs), enriched for association with breast cancer, were tested for interaction with 10 environmental risk factors using three recently proposed hybrid methods and a joint test of association and interaction. Analyses were a..

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University of Melbourne Researchers

Roger Milne Author

Enes Makalic Author

Daniel Schmidt Author Melbourne School of Population and Global Health

Melissa Southey Author

Related Projects (2)

NIH AUSTRALIAN BREAST CANCER FAMILY REGISTRY SOUTHEY-HOPPER

DESCRIPTION (provided by applicant): The broad objective of the Breast Cancer Family Registry (Breast CFR) is to establish and maintain a hy..

Epidemiology of chronic disease, health interventions and DNA studies

Grants

Awarded by Canadian Institutes of Health Research

Funding Acknowledgements

Funding for the iCOGS infrastructure came from the European Community's Seventh Framework Programme under grant agreement 223175 (HEALTH-F2-2009-223175, COGS), Cancer Research UK (C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692), the National Institutes of Health (CA128978), and Post-Cancer GWAS initiative (1U19 CA148537, 1U19 CA148065, and 1U19 CA148112-the GAME-ON initiative), the Department of Defence (W81XWH-10-1-0341), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund.